Article
Clinical correlates of NRAS and BRAF mutations in primary human melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2011
Ellerhorst Julie A, Greene Victoria R, Ekmekcioglu Suhendan, Warneke Carla L, Johnson Marcella M, Cooke Carolyn P, Wang Li-E, Prieto Victor G, Gershenwald Jeffrey E, Wei Qingyi, Grimm Elizabeth A
Abstract excerpt
PURPOSE: NRAS and BRAF mutations are common in cutaneous melanomas, although rarely detected mutually in the same tumor. Distinct clinical correlates of these mutations have not been described, despite in vitro data suggesting enhanced oncogenic effects. This study was designed to test the hypothesis that primary human cutaneous melanomas harboring mutations in NRAS or BRAF display a more aggressive clinical...
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