Article
RAC1 P29S regulates PD-L1 expression in melanoma.
Pigment cell & melanoma research - 1 Sept 2015
Vu Ha Linh, Rosenbaum Sheera, Purwin Timothy J, Davies Michael A, Aplin Andrew E
Abstract excerpt
Whole exome sequencing of cutaneous melanoma has led to the detection of P29 mutations in RAC1 in 5-9% of samples, but the role of RAC1 P29 mutations in melanoma biology remains unclear. Using reverse phase protein array analysis to examine the changes in protein/phospho-protein expression, we identified cyclin B1, PD-L1, Ets-1, and Syk as being selectively upregulated with RAC1 P29S expression and downregulated...
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