Article

A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition

2024-12-23

Abstract excerpt

The Rac1 P29S hotspot mutation in cutaneous melanoma is associated with resistance to MAPK pathway inhibitors (MAPKi) and worse clinical outcomes. Moreover, activation of Rac1 guanine exchange factors (GEFs) also promotes MAPKi-resistance, particularly in undifferentiated melanoma cells. Here we delineate mechanisms of Rac1-driven MAPKi-resistance and identify strategies to inhibit the growth of this class of cuta...

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Literature Corpus work: 2f72e603-cfe7-5182-ac3e-d9b66575cb9b
DOI: 10.1101/2024.12.22.629990

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