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Article

Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia.

Journal of psychiatric research - 1 Oct 2014

Ma Liang, Wu Dong-Dong, Ma Suk Ling, Tan Liwen, Chen Xiaogang, Tang Nelson L S, Yao Yong-Gang

Abstract excerpt

CREB1 is a cAMP responsive transcriptional factor which plays a key role in neural development. CREB1 signal pathway (CSP) has been implicated repeatedly in studies of predisposition for schizophrenia. We speculated that CSP has undergone positive selection during evolution of modern human and some genes that have undergone natural selection in the past may predispose to schizophrenia (SCZ) in modern time....

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Source

Identifiers

PMID: 25043418
DOI: 10.1016/j.jpsychires.2014.06.008

Genes

NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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