Article
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.
Nature - 14 Aug 2014
Moltke Ida, Grarup Niels, Jørgensen Marit E, Bjerregaard Peter, Treebak Jonas T, Fumagalli Matteo, Korneliussen Thorfinn S, Andersen Marianne A, Nielsen Thomas S, Krarup Nikolaj T, Gjesing Anette P, Zierath Juleen R, Linneberg Allan, Wu Xueli, Sun Guangqing, Jin Xin, Al-Aama Jumana, Wang Jun, Borch-Johnsen Knut, Pedersen Oluf, Nielsen Rasmus, Albrechtsen Anders, Hansen Torben
Abstract excerpt
The Greenlandic population, a small and historically isolated founder population comprising about 57,000 inhabitants, has experienced a dramatic increase in type 2 diabetes (T2D) prevalence during the past 25 years. Motivated by this, we performed association mapping of T2D-related quantitative traits in up to 2,575 Greenlandic individuals without known diabetes. Using array-based genotyping and exome sequencing,...
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