Article
Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population.
Diabetologia - 1 Sept 2018
Grarup Niels, Moltke Ida, Andersen Mette K, Bjerregaard Peter, Larsen Christina V L, Dahl-Petersen Inger K, Jørsboe Emil, Tiwari Hemant K, Hopkins Scarlett E, Wiener Howard W, Boyer Bert B, Linneberg Allan, Pedersen Oluf, Jørgensen Marit E, Albrechtsen Anders, Hansen Torben
Abstract excerpt
AIMS/HYPOTHESIS: In a recent study using a standard additive genetic model, we identified a TBC1D4 loss-of-function variant with a large recessive impact on risk of type 2 diabetes in Greenlanders. The aim of the current study was to identify additional genetic variation underlying type 2 diabetes using a recessive genetic model, thereby increasing the power to detect variants with recessive effects. METHODS: We...
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