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Article

Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers.

Diabetologia - 1 Aug 2021

Schnurr Theresia M, Jørsboe Emil, Chadt Alexandra, Dahl-Petersen Inger K, Kristensen Jonas M, Wojtaszewski Jørgen F P, Springer Christian, Bjerregaard Peter, Brage Søren, Pedersen Oluf, Moltke Ida, Grarup Niels, Al-Hasani Hadi, Albrechtsen Anders, Jørgensen Marit E, Hansen Torben

Abstract excerpt

AIMS/HYPOTHESIS: The common muscle-specific TBC1D4 p.Arg684Ter loss-of-function variant defines a subtype of non-autoimmune diabetes in Arctic populations. Homozygous carriers are characterised by elevated postprandial glucose and insulin levels. Because 3.8% of the Greenlandic population are homozygous carriers, it is important to explore possibilities for precision medicine. We aimed to investigate whether...

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Identifiers

PMID: 33912980
DOI: 10.1007/s00125-021-05461-z
PMCID: PMC8245392

Genes

TBC1D4

Variants

Provenance

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