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Article

TBC1D4-Related Monogenic Diabetes: Molecular Mechanisms, Clinical Recognition, and Therapeutic Implications.

Journal of diabetes - 1 Aug 2026

Wang Wenjing, Ma Lidan, Dong Bingzi, Gao Peihan, Sun Xiaofang

Abstract excerpt

Monogenic diabetes caused by TBC1D4 mutations is a relatively rare hereditary disorder of glucose metabolism that has increasingly gained attention in recent years. The protein encoded by this gene plays a pivotal regulatory role in glucose transport within skeletal muscle and adipose tissue; its dysfunction leads to significant insulin resistance and glucose dysregulation characterized by predominant...

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Identifiers

PMID: 42629605
DOI: 10.1111/1753-0407.70266
PMCID: PMC13498702

Genes

TBC1D4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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