Article
Inflammasome and Its Therapeutic Targeting in Rheumatoid Arthritis.
Frontiers in immunology - 1 Jan 2021
Jiang Qi, Wang Xin, Huang Enyu, Wang Qiao, Wen Chengping, Yang Guocan, Lu Liwei, Cui Dawei
Abstract excerpt
Inflammasome is a cytoplasmic multiprotein complex that facilitates the clearance of exogenous microorganisms or the recognition of endogenous danger signals, which is critically involved in innate inflammatory response. Excessive or abnormal activation of inflammasomes has been shown to contribute to the development of various diseases including autoimmune diseases, neurodegenerative changes, and cancers....
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