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Article

Negative regulation of NLRP3 inflammasome signaling

21 Mar 2013

Abstract excerpt

Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of inflammasomes have been described, the NLRP3 inflammasome is the most extensively studied. NLRP3 inflammasome is triggered by a variety of stimuli, including infection, tissue damage and metabolic dysregulation, and then activated through an...

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PMID: 23519777
DOI: 10.1007/s13238-013-2128-8

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