Article
Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells.
Methods in cell biology - 1 Jan 2017
Iwanami N, Hess I, Schorpp M, Boehm T
Abstract excerpt
Traditionally, transplantation has been a major experimental procedure to study the development and function of hematopoietic and immune systems. Here, we describe the use of a zebrafish strain lacking definitive hematopoiesis (cmybI181N) for interspecific analysis of hematopoietic and immune cell development. Without conditioning prior to transplantation, allogeneic and xenogeneic hematopoietic progenitor cells...
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