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Article

Molecular determinants of tetramerization in the KcsA cytoplasmic domain.

Protein science : a publication of the Protein Society - 1 Oct 2014

Kamnesky Guy, Hirschhorn Orel, Shaked Hadassa, Chen Jingfei, Yao Lishan, Chill Jordan H

Abstract excerpt

The cytoplasmic C-terminal domain (CTD) of KcsA, a bacterial homotetrameric potassium channel, is an amphiphilic domain that forms a helical bundle with four-fold symmetry mediated by hydrophobic and electrostatic interactions. Previously we have established that a CTD-derived 34-residue peptide associates into a tetramer in a pH-dependent manner (Kamnesky et al., JMB 2012;418:237-247). Here we further...

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Identifiers

PMID: 25042120
DOI: 10.1002/pro.2525
PMCID: PMC4287001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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