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Article

Structural, thermodynamic, and kinetic effects of a phosphomimetic mutation in dynein light chain LC8.

Biochemistry - 8 Dec 2009

Benison Gregory, Chiodo Marcus, Karplus P Andrew, Barbar Elisar

Abstract excerpt

Dynein light chain LC8 is a small, dimeric, very highly conserved globular protein first identified as an integral part of the dynein and myosin molecular motors but now recognized as a dimerization hub with wider significance. Phosphorylation at Ser88 is thought to be involved in regulating LC8 in the apoptotic pathway. The phosphomimetic Ser88Glu mutation weakens dimerization of LC8 and thus its overall...

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Identifiers

PMID: 19863079
DOI: 10.1021/bi901589w
PMCID: PMC2821902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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