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Article

Rearrangements in the KcsA cytoplasmic domain underlie its gating.

The Journal of biological chemistry - 5 Feb 2010

Hirano Minako, Takeuchi Yuko, Aoki Takaaki, Yanagida Toshio, Ide Toru

Abstract excerpt

A change of cytosolic pH 7 to 4 opens the bacterial potassium channel KcsA. However, the overall gating mechanism leading to channel opening, especially the contribution of the cytoplasmic domain, remains unsolved. Here we report that deletion of the cytoplasmic domain resulted in changes in channel conductance and gating behavior at pH 4 without channel opening at pH 7. To probe for rearrangements in the...

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Identifiers

PMID: 19959477
DOI: 10.1074/jbc.M109.084368
PMCID: PMC2823519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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