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Article

Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001

Fleming K G, Engelman D M

Abstract excerpt

The folding, stability, and oligomerization of helical membrane proteins depend in part on a precise set of packing interactions between transmembrane helices. To understand the energetic principles of these helix-helix interactions, we have used alanine-scanning mutagenesis and sedimentation equ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11724930
DOI: 10.1073/pnas.251367498
PMCID: PMC64683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11724930-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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