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Article

Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle

27 May 2016

Abstract excerpt

Deoxynucleotide triphosphates (dNTPs) are essential for efficient hepatitis B virus (HBV) replication. Here, we investigated the influence of the restriction factor SAMHD1, a dNTP hydrolase (dNTPase) and RNase, on HBV replication. We demonstrated that silencing of SAMHD1 in hepatic cells increased HBV replication, while overexpression had the opposite effect. SAMHD1 significantly affected the levels of...

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PMID: 27229711
DOI: 10.1038/srep26616

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