Article
Functional analysis and molecular characterization of spontaneously outgrown human lymphoblastoid cell lines.
Molecular biology reports - 1 Oct 2014
Bernig Toralf, Richter Nicole, Volkmer Ines, Staege Martin S
Abstract excerpt
In vitro, the infection of human B-cells with the lymphotropic gammaherpesvirus Epstein-Barr virus (EBV) induces formation of permanently growing lymphoblastoid cell lines (LCL). In a spontaneously outgrown LCL (cell line CSIII), we detected nucleotide sequence variations of the EBV nuclear antigen 1 (EBNA1) RNA that was different from the reference sequence of EBNA1 in the prototypic EBV strain B95-8. In the...
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