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Utility of lymphoblastoid cell lines

17 Feb 2009

Abstract excerpt

Transformation of peripheral B lymphocytes by Epstein-Barr virus (EBV) is the method of choice for generating lymphoblastoid cell lines (LCLs). This method has been in use for the last two decades with a high success rate. With a somatic mutation rate of 0.3% and ease of cell maintenance, lymphoblastoid cells are still the preferred choice of storage for patients' genetic material. Studies have demonstrated a...

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PMID: 19224581
DOI: 10.1002/jnr.22000

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