Article
The impact of TP53 and RAS mutations on cerebellar glioblastomas.
Experimental and molecular pathology - 1 Oct 2014
Milinkovic Vedrana P, Skender Gazibara Milica K, Manojlovic Gacic Emilija M, Gazibara Tatjana M, Tanic Nikola T
Abstract excerpt
Cerebellar glioblastoma (cGBM) is a rare, inadequately characterized disease, without detailed information on its molecular basis. This is the first report analyzing both TP53 and RAS alterations in cGBM. TP53 mutations were detected in more than half of the samples from our cohort, mainly in hotspot codons. There were no activating mutations in hotspot codons 12/13 and 61 of KRAS and HRAS genes in cGBM samples...
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