Article
Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors.
Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 2008
Sazinsky Stephen L, Ott René G, Silver Nathaniel W, Tidor Bruce, Ravetch Jeffrey V, Wittrup K Dane
Abstract excerpt
Immunoglobulin G plays a vital role in adaptive immunity and antibody-based therapy through engagement of its Fc region by the Fc gamma receptors (Fc gammaRs) on immune cells. In addition to specific protein-protein contacts, N-linked glycosylation of the IgG Fc has been thought to be essential for the recognition of Fc by Fc gammaR. This requirement for the N-linked glycan has limited biomanufacture of...
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