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Article

Engineering the fragment crystallizable (Fc) region of human IgG1 multimers and monomers to fine-tune interactions with sialic acid-dependent receptors.

The Journal of biological chemistry - 4 Aug 2017

Blundell Patricia A, Le Ngoc Phuong Lan, Allen Joel, Watanabe Yasunori, Pleass Richard J

Abstract excerpt

Multimeric fragment crystallizable (Fc) regions and Fc-fusion proteins are actively being explored as biomimetic replacements for IVIG therapy, which is deployed to manage many diseases and conditions but is expensive and not always efficient. The Fc region of human IgG1 (IgG1-Fc) can be engineered into multimeric structures (hexa-Fcs) that bind their cognate receptors with high avidity. The critical influence of...

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Identifiers

PMID: 28620050
DOI: 10.1074/jbc.M117.795047
PMCID: PMC5546038

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