Article
The Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins
9 Oct 2006
Abstract excerpt
Immunoglobulins are the major secretory products of the adaptive immune system. Each is characterized by a distinctive set of glycoforms that reflects the wide variation in the number, type, and location of their oligosaccharides. In a given physiological state, glycoform populations are reproducible; therefore, disease-associated alterations provide diagnostic biomarkers (e.g., for rheumatoid arthritis) and...
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