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Article

A novel polymorphism in the promoter region of ERBB4 is associated with breast and colorectal cancer risk.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2007

Rokavec Matjaz, Justenhoven Christina, Schroth Werner, Istrate Monica Adina, Haas Susanne, Fischer Hans-Peter, Vollmert Caren, Illig Thomas, Hamann Ute, Ko Yon-Dschun, Glavac Damjan, Brauch Hiltrud

Abstract excerpt

PURPOSE: The receptor tyrosine kinase ERBB4/HER4 plays a role in cell division, migration, differentiation, as well as apoptosis, and is frequently overexpressed in breast and colorectal tumors. To understand the role of genetic variations in the regulation of ERBB4 expression, we identified new polymorphisms and investigated their functional implication and risk association with breast and colorectal cancer....

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Electrophoretic Mobility Shift Assay

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Share to Receptor, ErbB-4

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Source

Identifiers

PMID: 18094435
DOI: 10.1158/1078-0432.CCR-07-0457

Genes

ERBB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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