Article
Tumor-promoting function of single nucleotide polymorphism rs1836724 (C3388T) alters multiple potential legitimate microRNA binding sites at the 3'-untranslated region of ErbB4 in breast cancer.
Molecular medicine reports - 1 May 2016
Bagheri Fatemeh, Mesrian Tanha Hamzeh, Mojtabavi Naeini Marjan, Ghaedi Kamran, Azadeh Mansoureh
Abstract excerpt
ErbB4 can act as either a tumor-suppressor gene or an oncogene in breast cancer. Multiple genetic factors including single nucleotide polymorphisms (SNPs) affect gene expression patterns. Multiple 3'-untranslated region (3'-UTR) SNPs reside within the target binding site of microRNAs, which can strengthen or weaken binding to target genes. The present study aimed to predict potential 3'‑UTR variants of ErbB4 that...
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