Article
Evaluation of human epidermal growth factor receptor 2 (HER2) single nucleotide polymorphisms (SNPs) in normal and breast tumor tissues and their link with breast cancer prognostic factors.
Breast (Edinburgh, Scotland) - 1 Dec 2016
Furrer Daniela, Lemieux Julie, Côté Marc-André, Provencher Louise, Laflamme Christian, Barabé Frédéric, Jacob Simon, Michaud Annick, Diorio Caroline
Abstract excerpt
Amplification of the human epidermal growth factor receptor 2 (HER2) gene is associated with worse prognosis and decreased overall survival in breast cancer patients. The HER2 gene contains several polymorphisms; two of the best-characterized HER2 polymorphisms are Ile655Val and Ala1170Pro. The aim of this study was to evaluate the association between these two HER2 polymorphisms in normal breast and breast...
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