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Article

Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance.

Cancer research - 1 Sept 2014

Ohba Shigeo, Mukherjee Joydeep, See Wendy L, Pieper Russell O

Abstract excerpt

Isocitrate dehydrogenase 1 (IDH1) mutations occur in most lower grade glioma and not only drive gliomagenesis but are also associated with longer patient survival and improved response to temozolomide. To investigate the possible causative relationship between these events, we introduced wild-typ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25035396
DOI: 10.1158/0008-5472.CAN-14-0924
PMCID: PMC4154998

Genes

IDH1
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25035396-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance.PMID 25035396Read ↗

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