Article
Association between mutant IDHs and tumorigenesis in gliomas.
Medical molecular morphology - 1 Dec 2018
Ohba Shigeo, Hirose Yuichi
Abstract excerpt
To become immortalized, cells need to maintain the telomere length via the activation of telomerase or alternative lengthening of telomere. Mutations in IDH1/2 are strongly associated with the early stage of gliomagenesis. Previous work has shown that the accumulation of 2-HG, which is induced by mutant IDH1/2, inhibits α-KG-dependent deoxygenase and leads to genome-wide histone and DNA methylation alterations....
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