Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice.

doi:10.1189/jlb.6A0114-004RR

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Article

Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice.

Journal of leukocyte biology - 1 Oct 2014

Wang Meng, You Qiang, Lor Kenton, Chen Fangfang, Gao Bin, Ju Cynthia

Abstract excerpt

Hepatic Macs, consisting of resident KCs and infiltrating monocytes/IMs, are thought to play an important role in the pathogenesis of ALD. Previous work has focused on KCs or studied hepatic Macs as one cell population. The aim of the current study is to distinguish IMs from KCs and to compare their phenotypes and functions. We show here that a 4-week ethanol feeding of C57BL/6J mice causes recruitment of IMs...

Topics

Alcohol Drinking
Animals
Antigens, Ly
Female
Immunophenotyping
Interferon-alpha
Interferon-gamma
Kupffer Cells
Liver
Liver Function Tests
Male
Mice
Monocytes
Phagocytes
Phenotype

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Identifiers

PMID: 25030420
DOI: 10.1189/jlb.6A0114-004RR
PMCID: PMC4163632

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