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Article

Local-anesthetic like inhibition of the cardiac sodium channel Nav1.5 α-subunit by 5-HT3 receptor antagonists.

European journal of pharmacology - 15 Oct 2016

Van't Klooster Mariet P, Foadi Nilufar, Hage Axel, Stoetzer Carsten, Wegner Florian, Eberhardt Mirjam, Leffler Andreas

Abstract excerpt

5-hydroxytryptamine 3 receptor (5-HT3 receptor) antagonists are administered for prevention and therapy of nausea and vomiting. Although regarded as safe therapeutics, they can also provoke arrhythmias by prolonging the QRS interval. However, the mechanisms mediating this cardiotoxicity are poorly understood. Here we investigated effects of 5-HT3 receptor antagonists on the cardiac Na(+) channel Nav1.5. We...

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Identifiers

PMID: 27401036
DOI: 10.1016/j.ejphar.2016.07.020

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