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Article

Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome.

Circulation. Arrhythmia and electrophysiology - 1 Oct 2013

Veerman Christiaan C, Verkerk Arie O, Blom Marieke T, Klemens Christine A, Langendijk Pim N J, van Ginneken Antoni C G, Wilders Ronald, Tan Hanno L

Abstract excerpt

BACKGROUND: Drug-induced long QT syndrome is generally ascribed to inhibition of the cardiac rapid delayed rectifier potassium current (IKr). Effects on the slow delayed rectifier potassium current (IKs) are less recognized. Triggered by a patient who carried the K422T mutation in KCNQ1 (encoding the α-subunit of the IKs channel), who presented with excessive QT prolongation and high serum levels of...

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Source

Identifiers

PMID: 23995305
DOI: 10.1161/CIRCEP.113.000239

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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