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Article

Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition.

Neuron - 13 Nov 2003

Gomeza Jesús, Hülsmann Swen, Ohno Koji, Eulenburg Volker, Szöke Katalin, Richter Diethelm, Betz Heinrich

Abstract excerpt

The glycine transporter subtype 1 (GlyT1) is widely expressed in astroglial cells throughout the mammalian central nervous system and has been implicated in the regulation of N-methyl-D-aspartate (NMDA) receptor activity. Newborn mice deficient in GlyT1 are anatomically normal but show severe motor and respiratory deficits and die during the first postnatal day. In brainstem slices from GlyT1-deficient mice, in...

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Identifiers

PMID: 14622582
DOI: 10.1016/s0896-6273(03)00672-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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