Article
Thymidine phosphorylase gene variant, platelet counts and survival in gastrointestinal cancer patients treated by fluoropyrimidines.
Scientific reports - 16 Jul 2014
Huang Liu, Chen Fengju, Chen Yangyang, Yang Xiaomei, Xu Sanpeng, Ge Shuwang, Fu Shengling, Chao Tengfei, Yu Qianqian, Liao Xin, Hu Guangyuan, Zhang Peng, Yuan Xianglin
Abstract excerpt
The predictive value of thymidine phosphorylase gene variants (TP, also called platelet-derived endothelial cell growth factor) and thrombocytosis were controversial and worthy of further study in gastrointestinal cancer (GIC) patients. We screened all of the common missense single nucleotide polymorphisms (MAF ≥ 0.1) in fluoropyrimidines (FU) pathway genes (including TP, TS, ENOSF1 and DPD). Three of them were...
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