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Article

Prediction of severe toxicity in adult patients under treatment with 5-fluorouracil: a prospective cohort study.

Anti-cancer drugs - 1 Oct 2017

Vázquez Carolina, Orlova María, Angriman Federico, Minatta José N, Scibona Paula, Verzura María A, Jáuregui Esteban G, Díaz de Arce Heidy, Pallotta María G, Belloso Waldo H

Abstract excerpt

5-Fluorouracil (5-FU) has long been used for the treatment of gastrointestinal tumors harboring interindividual variability in both the pharmacokinetic and the pharmacogenetic profiles, which in turn may lead to life-threatening toxicities. We carried out a prospective cohort study of adult patients initiating treatment with 5-FU between 2013 and 2015. Primary exposures of interest were the...

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PMID: 28723867
DOI: 10.1097/CAD.0000000000000546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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