Article
Polymorphisms of dihydropyrimidine dehydrogenase gene and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population.
Chinese medical journal - 1 Mar 2012
Zhang Xiao-ping, Bai Zhi-bin, Chen Bao-an, Feng Ji-feng, Yan Feng, Jiang Zhi, Zhong Yue-jiao, Wu Jian-zhong, Chen Lu, Lu Zu-hong, Tong Na, Zhang Zheng-dong, Xu Pei-pei, Peng Miao-xin, Zhang Wen-jing, Wang Shuai
Abstract excerpt
BACKGROUND: Dihydropyrimidine dehydrogenase (DPD), a key enzyme involved in the catabolism of 5-fluorouracil (5-FU), is the attractive candidate for pharmacogenetic research on efficacies and toxicities of 5-FU. The aim of this study is to explore the association between polymorphisms of dihydropyrimidine dehydrogenase gene (DPYD) and clinical outcomes of gastric cancer patients treated with fluorouracil-based...
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