Article
Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation.
Archives of biochemistry and biophysics - 1 Dec 2014
Mehrotra Aanchal, Saladi Srinivas Vinod, Trivedi Archit R, Aras Shweta, Qi Huiling, Jayanthy Ashika, Setaluri Vijayasaradhi, de la Serna Ivana L
Abstract excerpt
Brahma (BRM) and Brahma-related gene 1(BRG1) are catalytic subunits of SWItch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes. BRM is epigenetically silenced in a wide-range of tumors. Mutations in the v-raf murine sarcoma viral oncogene homolog B1 (BRAF) gene occur frequently in melanoma and lead to constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal...
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