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Article

The BRAFV600E causes widespread alterations in gene methylation in the genome of melanoma cells

15 Jan 2012

Abstract excerpt

Although BRAF(V600E) is well known to play an important role in the tumorigenesis of melanoma, its molecular mechanism, particularly the epigenetic aspect, has been incompletely understood. Here, we investigated the role of BRAF(V600E) signaling in altering gene methylation in the genome of melanoma cells using a methylated CpG island amplification/CpG island microarray system and searched for genes coupled to...

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Share to Cutaneous Melanoma Detection and Management
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PMID: 22189819
DOI: 10.4161/cc.11.2.18707

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