Article
BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases.
Neoplasia (New York, N.Y.) - 1 Sept 2020
Grigore Florina, Yang Hana, Hanson Nicholas D, VanBrocklin Matthew W, Sarver Aaron L, Robinson James P
Abstract excerpt
The development of mutant BRAF inhibitors has improved the outcome for melanoma patients with BRAFV600E mutations. Although the initial response to these inhibitors can be dramatic, sometimes resulting in complete tumor regression, the majority of melanomas become resistant. To study resistance to BRAF inhibition, we developed a novel mouse model of melanoma using a tetracycline/doxycycline-regulated system that...
Topics
- Animals
- Apoptosis
- Cell Proliferation
- Cyclin-Dependent Kinase Inhibitor p16
- Drug Resistance, Neoplasm
- Female
- Histone Methyltransferases
- Histones
- Male
- Melanoma, Experimental