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Article

Brahma-Related Gene-1 (BRG1) promotes the malignant phenotype of glioblastoma cells.

Journal of cellular and molecular medicine - 1 Mar 2021

Wang Yinan, Yang Chuan He, Schultz Andrew P, Sims Michelle M, Miller Duane D, Pfeffer Lawrence M

Abstract excerpt

Glioblastoma multiforme (GBM) is an aggressive malignant brain tumour that is resistant to existing therapeutics. Identifying signalling pathways deregulated in GBM that can be targeted therapeutically is critical to improve the present dismal prognosis for GBM patients. In this report, we have identified that the BRG1 (Brahma-Related Gene-1) catalytic subunit of the SWI/SNF chromatin remodelling complex promotes...

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Identifiers

PMID: 33528916
DOI: 10.1111/jcmm.16330
PMCID: PMC7957270

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