Article
Pharmacogenetics of quetiapine in healthy volunteers: association with pharmacokinetics, pharmacodynamics, and adverse effects.
International clinical psychopharmacology - 1 Mar 2015
Cabaleiro Teresa, López-Rodríguez Rosario, Román Manuel, Ochoa Dolores, Novalbos Jesús, Borobia Alberto, Carcas Antonio, Abad-Santos Francisco
Abstract excerpt
Quetiapine is an atypical antipsychotic used for treatment of schizophrenia. Variability in response to this drug may be associated with pharmacogenetics. The aim of this study was to identify genetic markers related to the pharmacokinetics, pharmacodynamics, and adverse effects of quetiapine. The study population comprised 79 healthy volunteers from two bioequivalence trials who were genotyped to identify...
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