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Article

MDR-1 genotypes and quetiapine pharmacokinetics in healthy volunteers.

Drug metabolism and drug interactions - 1 Jan 2013

González-Vacarezza Nicolás, Dorado Pedro, Peñas-Lledó Eva M, Fariñas Humberto, Estévez-Carrizo Francisco E, Llerena Adrián

Abstract excerpt

BACKGROUND: P-glycoprotein is an efflux transporter encoded by the multidrug-resistance MDR-1 gene, which influences the absorption and excretion of a variety of drugs. The relation between quetiapine pharmacokinetics and MDR-1 genetic polymorphisms remains controversial. Therefore, the aim of the present study was to analyze the association between quetiapine plasma concentrations and MDR-1 genetic polymorphisms...

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Identifiers

PMID: 23740681
DOI: 10.1515/dmdi-2013-0008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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