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Article

The effect of CYP2D6 variation on antipsychotic-induced hyperprolactinaemia: a systematic review and meta-analysis.

The pharmacogenomics journal - 1 Oct 2020

Calafato Maria Stella, Austin-Zimmerman Isabelle, Thygesen Johan H, Sairam Mani, Metastasio Antonio, Marston Louise, Abad-Santos Francisco, Bhat Anjali, Harju-Seppänen Jasmine, Irizar Haritz, Zartaloudi Eirini, Bramon Elvira

Abstract excerpt

Hyperprolactinemia is a known adverse drug reaction to antipsychotic treatment. Antipsychotic blood levels are influenced by cytochrome P450 enzymes, primarily CYP2D6. Variation in CYP450 genes may affect the risk of antipsychotic-induced hyperprolactinemia. We undertook a systematic review and meta-analysis to assess whether CYP2D6 functional genetic variants are associated with antipsychotic-induced...

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PMID: 32015455
DOI: 10.1038/s41397-019-0142-9

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