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Article

ERCC1 Cys8092Ala and XRCC1 Arg399Gln polymorphisms predict progression-free survival after curative radiotherapy for nasopharyngeal carcinoma.

PloS one - 1 Jan 2014

Jin Hekun, Xie Xiaoxue, Wang Hui, Hu Jun, Liu Feng, Liu Zhigang, Zhou Jumei, Zhang Yingying, Xi Xuping, Hu Bingqiang, Liao Yuping, Tang Jingtian

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) in DNA repair genes can alter gene expression and activity and affect response to cancer treatment and, correspondingly, survival. The present study was designed to evaluate the utility of the XRCC1 Arg399Gln and ERCC1 Cys8092Ala SNPs, measured in pretreatment biopsy samples, as predictors of response to radiotherapy in patients with non-metastatic nasopharyngeal...

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Source

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Identifiers

PMID: 25025378
DOI: 10.1371/journal.pone.0101256
PMCID: PMC4099069

Genes

ERCC1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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