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Article

Single nucleotide polymorphisms in nucleotide excision repair genes, cancer treatment, and head and neck cancer survival.

Cancer causes & control : CCC - 1 Apr 2014

Wyss Annah B, Weissler Mark C, Avery Christy L, Herring Amy H, Bensen Jeannette T, Barnholtz-Sloan Jill S, Funkhouser William K, Olshan Andrew F

Abstract excerpt

PURPOSE: Head and neck cancers (HNC) are commonly treated with radiation and platinum-based chemotherapy, which produce bulky DNA adducts to eradicate cancerous cells. Because nucleotide excision repair (NER) enzymes remove adducts, variants in NER genes may be associated with survival among HNC cases both independently and jointly with treatment. METHODS: Cox proportional hazards models were used to estimate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24487794
DOI: 10.1007/s10552-014-0346-x
PMCID: PMC4096829

Genes

ERCC2
ERCC4
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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