Article
Single-nucleotide polymorphisms in base excision repair, nucleotide excision repair, and double strand break genes as markers for response to radiotherapy in patients with Stage I to II head-and-neck cancer.
International journal of radiation oncology, biology, physics - 15 Nov 2006
Carles Joan, Monzo Mariano, Amat Marta, Jansa Sonia, Artells Rosa, Navarro Alfons, Foro Palmira, Alameda Francesc, Gayete Angel, Gel Bernat, Miguel Maribel, Albanell Joan, Fabregat Xavier
Abstract excerpt
PURPOSE: Polymorphisms in DNA repair genes can influence response to radiotherapy. We analyzed single-nucleotide polymorphisms (SNP) in nine DNA repair genes in 108 patients with head-and-neck cancer (HNSCC) who had received radiotherapy only. METHODS AND MATERIALS: From May 1993 to December 2004, patients with Stage I and II histopathologically confirmed HNSCC underwent radiotherapy. DNA was obtained from...
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