Article
SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features.
Annals of surgical oncology - 1 Dec 2014
Li Tingting, Liao Xiaoyun, Lochhead Paul, Morikawa Teppei, Yamauchi Mai, Nishihara Reiko, Inamura Kentaro, Kim Sun A, Mima Kosuke, Sukawa Yasutaka, Kuchiba Aya, Imamura Yu, Baba Yoshifumi, Shima Kaori, Meyerhardt Jeffrey A, Chan Andrew T, Fuchs Charles S, Ogino Shuji, Qian Zhi Rong
Abstract excerpt
BACKGROUND: Smoothened, frizzled family receptor (SMO) is an important component of the hedgehog signaling pathway, which has been implicated in various human carcinomas. However, clinical, molecular, and prognostic associations of SMO expression in colorectal cancer remain unclear. METHODS: Using a database of 735 colon and rectal cancers in the Nurse's Health Study and the Health Professionals Follow-up Study,...
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