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Article

Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

Gastroenterology - 1 Aug 2009

Arimura Sumimasa, Matsunaga Akihiro, Kitamura Takanori, Aoki Koji, Aoki Masahiro, Taketo Makoto M

Abstract excerpt

BACKGROUND & AIMS: Although the Hedgehog (Hh) pathway regulates development and progression of several types of cancer, its involvement in colon cancer remains unclear. We aimed to clarify the roles of Hh signaling in intestinal tumorigenesis. METHODS: We studied expression of the Hh signaling components in the intestinal tumors of Apc(+/Delta716) mouse, a model for familial adenomatous polyposis. We used small...

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Source

Identifiers

PMID: 19427313
DOI: 10.1053/j.gastro.2009.04.059

Genes

SMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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