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Article

SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer

2 Feb 2018

Abstract excerpt

Colon Cancer (CC) is the fourth most frequently diagnosed tumor and the second leading cause of death in the USA. Abnormalities of Hedgehog pathway have been demonstrated in several types of human cancers, however the role of Hedgehog (Hh) in CC remain controversial. In this study, we analyzed the association between increased mRNA expression of GLI1 and GLI2, two Hh target genes, and CC survival and recurrence...

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Identifiers

PMID: 29456503
DOI: 10.3389/fphar.2017.00956

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