Article
Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells.
Cancer letters - 30 Apr 2004
Zhu Yanhua, James Roberta M, Peter Audrey, Lomas Claire, Cheung Francis, Harrison David J, Bader Scott A
Abstract excerpt
We investigated a role for Hedgehog signalling in colon cancer by studying transcription of members of the pathway in human colorectal carcinoma cell lines. We determined the methylation status and screened the gene encoding the Hedgehog receptor-associated protein Smoothened (SMO) for putative mutations. In three cell lines lacking SMO expression the SMO promoter was fully methylated and the transcription factor...
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