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Article

Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2012

Kakar Sanjay, Deng Guoren, Smyrk Thomas C, Cun Lisa, Sahai Vaibhav, Kim Young S

Abstract excerpt

The relationship of molecular abnormalities with clinicopathologic features and survival in colorectal signet ring cell carcinoma, and its comparison with mucinous and conventional adenocarcinomas, has not been well studied. High-level microsatellite instability, loss of heterozygosity (LOH) at f...

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Identifiers

PMID: 22522845
DOI: 10.1038/modpathol.2012.44

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22522845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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