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Article

Roles of interleukin-6 and macrophage inflammatory protein-2 in pneumolysin-induced lung inflammation in mice.

The Journal of infectious diseases - 1 Jan 2002

Rijneveld Anita W, van den Dobbelsteen Germie P, Florquin Sandrine, Standiford Theodore J, Speelman Peter, van Alphen Loek, van der Poll Tom

Abstract excerpt

Pneumolysin (PLY), a toxin synthesized by Streptococcus pneumoniae, is an important virulence factor in pneumococcal disease. This study evaluated the effects of PLY in lungs of mice. Intranasal inoculation with PLY was associated with a dose-dependent influx of polymorphonuclear leukocytes (PMNL...

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Source

Identifiers

PMID: 11756992
DOI: 10.1086/338008

Genes

MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11756992-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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